Serving East Setauket, Port Jefferson, Smithtown, St. James, Belle Terre, Poquott Village, Stony Brook & all of Suffolk County. How long does Botox last? Botox typically lasts 3–4 months, but everyone metabolizes it differently. Longevity depends on muscle strength, metabolism, and lifestyle factors. Things that can make Botox wear off faster include: Frequent exercise Fast metabolism Sun exposure/tanning Stress and strong muscle movement. When it comes to Botox treatments in